PURPOSE: To report that acute lamotrigine poisoning may result in severe encephalopathy. METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy. RESULTS: LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels. CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTG toxicity should be considered in patients taking this drug who have depressed mental status.
No takes yet. Share an insight, caveat, or question.
Sbei et al. (2001) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: