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The immunologic consequences of replacement therapy have been studied in 2 pairs of young haemophilic monozygotic twins. In both pairs one cotwin only developed a factor VIII specific antibody. This non‐concordance illustrates the influence upon a specific immune response of non‐genetic factors since the blood products, administered to each brother‐pair, were not at all time identical nor were the regimens of transfusion therapy.
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Frommel et al. (1979) studied this question.
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