Regulation of Macrophage Polarization and Tumor Immunosuppression in Glioblastoma

Macrophage polarization is the polarization of a series of functional states after activation of monocytes, and different microenvironmental stimuli can regulate their differentiation. Macrophage is not only an important component of the tumor microenvironment, but also an essential part of it. By interacting with various factors, it regulates the growth, invasion, metastasis, and lymphangiogenesis of the tumor. The increase in the number and density of macrophages such as glioblastoma is closely related to the malignancy of the tumor. Nearly 80% of studies have shown that the number of macrophages in tumor tissues is associated with poor prognosis. Exploring the molecular mechanism of macrophage polarization regulation can contribute to a deeper understanding of the pathogenesis of related diseases and provide new ideas for the development of novel anti-tumor drugs.