Why the study?
There is no established effective treatment for myocardial ischemia/reperfusion injury in patients with acute STEMI.
Does Shexiang Baoxin Pill added to primary PCI improve myocardial salvage and reduce infarct size in patients with STEMI?
Does Shexiang Baoxin Pill added to primary PCI improve myocardial salvage and reduce infarct size in patients with STEMI?
Adding Shexiang Baoxin Pill to primary PCI for STEMI patients significantly improved myocardial salvage and reduced infarct size compared to primary PCI alone.
Answers are grounded in this paper and cite their sources.
May reduce I/R injury and infarct size with PPCI in STEMI; leaves open confirmation of clinical benefit in larger trials.
Background: There is no definite effect in the treatment of myocardial ischemia/reperfusion (I/R) injury in patients with acute ST-segment elevation myocardial infarction (STEMI). We evaluated the protective effect of Shexiang Baoxin Pill (SBP) on I/R injury in STEMI patients. Methods: STEMI patients were randomly divided into a primary percutaneous coronary intervention (PPCI) group (n = 52) and a PPCI + SBP group (n = 51). The area at risk of infarction (AAR) and final infarct size (FIS) were examined by single-photon emission computed tomography (SPECT). I/R injury was assessed using myocardial salvage (MS) and salvage index (SI) calculated from AAR and FIS. Results: The ST-segment resolution (STR) in the PPCI + SBP group was significantly higher than that in the PPCI group ( p = 0.036), and the peak value of high-sensitivity troponin T (hsTNT) was lower than that in the PPCI group ( p = 0.048). FIS in the PPCI + SBP group was smaller than that in the PPCI group ( p = 0.047). MS ( p = 0.023) and SI ( p = 0.006) in the PPCI + SBP group were larger than those in the PPCI group. The left ventricular ejection fraction (LVEF) in the PPCI + SBP group was higher than that in the PPCI group ( p = 0.049), and N-terminal pro-B type natriuretic peptide (NT-proBNP) level in the PPCI + SBP group was lower than that in the PPCI group ( p = 0.048). Conclusions: SBP can alleviate I/R injury (MS and SI), decrease myocardial infarction area (peak value of hsTNT and FIS), and improve myocardial reperfusion (MBG and STR) and cardiac function (LVEF and NT-proBNP).
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Qin et al. (2021) studied this question.
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