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January 1, 1995The Journal of Experimental MedicineOpen Access

Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase.

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Population

Endothelioma cell lines transformed by polyoma virus middle T antigen and endothelioma-bearing syngeneic mice

Comparison

NOS inhibitor L-canavanine (in vivo) vs Nontransformed control cells (in vitro)

Design

Preclinical

Authors

DGDario GhigoUniversity of TurinMAMarco AreseCandiolo Cancer InstituteRTRoberta ToddeInstitute of Protein Biochemistry

Discussion

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Implication

Hypothesis-generating for NOS inhibition in endothelial tumors; clinical translation remains untested.

Structured PICO

P
Population
Endothelioma cell lines transformed by polyoma virus middle T antigen (mTa) and endothelioma-bearing syngeneic mice
I
Intervention
NOS inhibitor L-canavanine (in vivo)
C
Comparator
Nontransformed control cells (in vitro)
O
Outcome
Nitric oxide (NO) production, NOS activity, tumor volume, and relapse timesurrogate

NOS hyperactivity in mTa-transformed endothelial cells contributes to hemangioma development, which can be attenuated by NOS inhibition.

Cite This Study

Ghigo et al. (1995) studied this question.

synapsesocial.com/papers/6a7e8c17db273b4b46797dc2https://doi.org/10.1084/jem.181.1.9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The release of platelet-activating factor from human endothelial cells in culture.1983 · 432 citations
  2. 2Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization.1993 · 276 citations
  3. 3Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.1992 · 993 citations
  4. 4Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.1989 · 1,451 citations
  5. 5Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.1989 · 1,851 citations