Why the study?
Steatotic liver disease now encompasses five distinct subcategories, prompting a summary of foundational and recent advances in its histologic evaluation.
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Design
Review
This review summarizes the foundational and recent advances in the histologic evaluation and categorization of steatotic liver disease.
Steatotic liver disease (SLD) is now used as an overarching category encompassing five subcategories: metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic and alcohol related/associated liver disease (MetALD), alcohol-related/associated liver disease (ALD), SLD with specific etiology, and cryptogenic SLD. This review summarizes foundational and recent advances in the histologic evaluation of SLD, including common pathologic features across all subcategories, distinctions associated with different etiologies, scoring and grading systems, and the evolution of digital pathology techniques for SLD assessment.
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Jiao et al. (2025) studied this question.
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