Seven of 160 patients receiving prolonged courses of doxycycline for moderate-severe acne developed uncommon side-effects. Five patients (3.1%) developed a photosensitive rash. In four of these this developed when the patients were abroad and they were subsequently able to continue the drug. Two patients (1.25%) developed symptoms of oesophagitis and had to discontinue therapy.
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Henderson et al. (1989) studied this question.
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