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January 1, 2004Bioscience Biotechnology and BiochemistryOpen Access

The 9cis,11trans,13cisIsomer of Conjugated Linolenic Acid Reduces Apolipoprotein B100 Secretion and Triacylglycerol Synthesis in HepG2 Cells

Keisuke Arao Hiroaki Yotsumoto Seo-Young Han Koji Nagao Teruyoshi Yanagita

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Abstract

The physiological effects of 9cis,11trans,13cis-conjugated linolenic acid (9c,11t,13c-CLNA), one of the CLNA isomers, were studied in human hepatoma HepG2 cells. 9c,11t,13c-CLNA significantly decreased apolipoprotein B100 secretion compared with alpha-linolenic acid (alpha-LNA). The uptake of (14)C-oleate into newly synthesized cellular triacylglycerol was also decreased by 9c,11t,13c-CLNA more than by alpha-LNA treatment. This is the first study to show the hypolipidemic effect of 9c,11t,13c-CLNA.

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Arao et al. (2004) studied this question.

synapsesocial.com/papers/6a7e90d1366dd125a6c2fb87 https://doi.org/10.1271/bbb.68.2643

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