December 3, 2012PLoS ONEOpen Access

Aortic aneurysms developed in 67% of vehicle-treated mice (n=15) with 40% rupture mortality, whereas no telmisartan-treated mouse developed an AAA (n=14).

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Why the study?

Do angiotensin II receptor blockers (telmisartan, irbesartan) prevent experimental abdominal aortic aneurysm progression in mouse models?

Population

Male ApoE mice with Ang II subcutaneous infusion for 28 days, and male C57BL/6 mice with transient…

Comparison

Irbesartan, telmisartan, fluvastatin, bosentan… vs Vehicle alone.

Design

Preclinical

Follow-up

28 days

Authors

YIYasunori IidaKanazawa University BXBaohui XuStanford Medicine GSGeoffrey M. SchultzPhoenix (United States)

Discussion

Member takes

Overview

Telmisartan prevented experimental AAA in mice; hypothesis-generating for clinical AAA prevention, pending human trials.

Structured PICO

Do angiotensin II receptor blockers (telmisartan, irbesartan) prevent experimental abdominal aortic aneurysm progression in mouse models?

Population

Male ApoE(-/-) mice with Ang II subcutaneous infusion (1000 ng/kg/min) for 28 days, and male C57BL/6 mice with transient intra-aortic porcine pancreatic elastase infusion.

Intervention

Irbesartan (50 mg/kg), telmisartan (10 mg/kg), fluvastatin (40 mg/kg), bosentan (100 mg/kg), or doxycycline (100 mg/kg) daily starting one week prior to AAA creation.

Comparator

Vehicle alone.

Outcome

Aortic diameter measurements, histopathology, and gene expression analysis at sacrifice.surrogate

Telmisartan and irbesartan suppress experimental abdominal aortic aneurysms in mouse models, highlighting their potential to limit clinical disease progression.

Cite This Study

Iida et al. (2012) studied this question.

synapsesocial.com/papers/6a7eae2bcb17bc2d1d0d25d9 https://doi.org/10.1371/journal.pone.0049642

View Full Paper

Ask AI

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December 3, 2012PLoS ONEOpen Access

Aortic aneurysms developed in 67% of vehicle-treated mice (n=15) with 40% rupture mortality, whereas no telmisartan-treated mouse developed an AAA (n=14).

View Full Paper

Ask AI

Bookmark

Why the study?

Do angiotensin II receptor blockers (telmisartan, irbesartan) prevent experimental abdominal aortic aneurysm progression in mouse models?

Population

Male ApoE mice with Ang II subcutaneous infusion for 28 days, and male C57BL/6 mice with transient…

Comparison

Irbesartan, telmisartan, fluvastatin, bosentan… vs Vehicle alone.

Design

Preclinical

Follow-up

28 days

Authors

YIYasunori IidaKanazawa University BXBaohui XuStanford Medicine GSGeoffrey M. SchultzPhoenix (United States)

Discussion

Member takes

Overview

Telmisartan prevented experimental AAA in mice; hypothesis-generating for clinical AAA prevention, pending human trials.

Structured PICO

Do angiotensin II receptor blockers (telmisartan, irbesartan) prevent experimental abdominal aortic aneurysm progression in mouse models?

Population

Male ApoE(-/-) mice with Ang II subcutaneous infusion (1000 ng/kg/min) for 28 days, and male C57BL/6 mice with transient intra-aortic porcine pancreatic elastase infusion.

Intervention

Irbesartan (50 mg/kg), telmisartan (10 mg/kg), fluvastatin (40 mg/kg), bosentan (100 mg/kg), or doxycycline (100 mg/kg) daily starting one week prior to AAA creation.

Comparator

Vehicle alone.

Outcome

Aortic diameter measurements, histopathology, and gene expression analysis at sacrifice.surrogate

Telmisartan and irbesartan suppress experimental abdominal aortic aneurysms in mouse models, highlighting their potential to limit clinical disease progression.

Cite This Study

Iida et al. (2012) studied this question.

synapsesocial.com/papers/6a7eae2bcb17bc2d1d0d25d9 https://doi.org/10.1371/journal.pone.0049642

View Full Paper

Ask AI

Bookmark