Make it enantioselective: The [(salen)AlIIICl] complex 1 catalyzes the title reaction of an aldehyde, a carboxylic acid, and an isocyanide to afford α-acyloxyamides 2 with good to excellent enantioselectivity. A variety of nonchelating substrates can be used to generate the versatile chiral products. R1=alkyl; R2=alkyl, alkenyl, aryl; R3=alkyl, aryl.
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Wang et al. (2007) studied this question.
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