Hypomagnesemia Induced by Several Proton-Pump Inhibitors

Letters17 November 2009Hypomagnesemia Induced by Several Proton-Pump InhibitorsMaarten A.C. Broeren, PhD, Engelien A.M. Geerdink, MD, Huib L. Vader, PhD, and A. Warmold L. van den Wall Bake, MD, PhDMaarten A.C. Broeren, PhDFrom Máxima Medical Centre, 5500 MB Veldhoven, The Netherlands., Engelien A.M. Geerdink, MDFrom Máxima Medical Centre, 5500 MB Veldhoven, The Netherlands., Huib L. Vader, PhDFrom Máxima Medical Centre, 5500 MB Veldhoven, The Netherlands., and A. Warmold L. van den Wall Bake, MD, PhDFrom Máxima Medical Centre, 5500 MB Veldhoven, The Netherlands.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-10-200911170-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Hypomagnesemia can cause serious neuromuscular and cardiovascular problems and is often accompanied by hypocalcemia and hypokalemia (1). Hypomagnesemia is sometimes caused by the proton-pump inhibitor (PPI) omeprazole (2–4).Objective: To present a case of hypomagnesemia induced by the PPIs omeprazole, pantoprazole, and lansoprazole.Case Report: A 58-year-old man was hospitalized because of loss of consciousness and convulsions while working in his garden. During this event, he did not bite his tongue or lose urine. He had not been ill recently but reported muscle cramps for several weeks. His medical history included esophagitis, pneumothorax, hypertension, hypercholesterolemia, a hip fracture, and ...References1. Agus ZS. Hypomagnesemia. J Am Soc Nephrol. 1999;10:1616-22. [PMID: 10405219] CrossrefMedlineGoogle Scholar2. Cundy T, Dissanayake A. Severe hypomagnesaemia in long-term users of proton-pump inhibitors. Clin Endocrinol (Oxf). 2008;69:338-41. [PMID: 18221401] CrossrefMedlineGoogle Scholar3. Epstein M, McGrath S, Law F. Proton-pump inhibitors and hypomagnesemic hypoparathyroidism [Letter]. N Engl J Med. 2006;355:1834-6. [PMID: 17065651] CrossrefMedlineGoogle Scholar4. Shabajee N, Lamb EJ, Sturgess I, Sumathipala RW. Omeprazole and refractory hypomagnesaemia. BMJ. 2008;337:a425. [PMID: 18617497] CrossrefMedlineGoogle Scholar5. Kupiec TC, Aloumanis V, Ben M, Trissel LA, Chan P, Patterson J. Physical and chemical stability of esomeprazole sodium solutions. Ann Pharmacother. 2008;42:1247-51. [PMID: 18614750] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Máxima Medical Centre, 5500 MB Veldhoven, The Netherlands.Disclosures: None disclosed. 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Following your stomach may hurt your heartCorrection: Hypomagnesemia Induced by Several Proton-Pump Inhibitors 17 November 2009Volume 151, Issue 10Page: 755-756KeywordsAttentionCalciumConvulsionsDrugsExcretionHypocalcemiaHypomagnesemiaMagnesiumPotassium ePublished: 17 November 2009 Issue Published: 17 November 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...