A striking feature of EMC discovered 20 years before the Hepatitis C Virus Infection and discovery of HCV was that monoclonal RF from different patients with the disease were identical as determined by Type II Cryoglobulinemia: An typing with an antibody that reacted with an epitope in the antigen-combining site of the RF called a ''cross-idiotype.'' 6
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Vincent Agnello (1997) studied this question.