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November 25, 2008Antimicrobial Agents and ChemotherapyOpen Access

CTX-M Expression and Selection of Ertapenem Resistance in Klebsiella pneumoniae and Escherichia coli

Delphine Girlich Laurent Poirel Patrice Nordmann

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Abstract

In vitro selection of mutants with decreased susceptibility to ertapenem was performed using Escherichia coli and Klebsiella pneumoniae clinical strains producing either the bla(CTX-M-2), bla(CTX-M-3), bla(CTX-M-9), or bla(CTX-M-15) gene. Frequencies of mutants with decreased susceptibilities to ertapenem were similar for all beta-lactamases expressed.

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Girlich et al. (2008) studied this question.

synapsesocial.com/papers/6a7eb8aa061146f178a6c68f https://doi.org/10.1128/aac.01007-08

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