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The first synthesis of both organic and aqueous soluble BF2 chelated 3,3'-dimethyl-5,5'-diarylazadipyrromethenes has been achieved. The fluorophores are emissive in organic and aqueous solvents with high quantum yields in the key biological near-infrared (NIR) spectral region of 675-700 nm. Following efficient cellular uptake from aqueous media the fluorophore can be readily visualized with confocal microscopy.
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Wu et al. (2013) studied this question.
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