June 1, 2003AJP Regulatory Integrative and Comparative Physiology

Guanylyl cyclase mediates ANP-induced vasoconstriction of murine splenic vessels

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Population

Small splenic arteries and veins dissected from male GC-A-deficient 129sv mice or age-matched wild-type…

Comparison

Atrial Natriuretic Peptide (ANP) vs Wild-type controls; intact vs denuded vessels

Design

Preclinical

Authors

PAPeter S. AndrewUniversity of Alberta SKSusan Kaufman

Discussion

Member takes

Implication

GC-A mediates ANP vasoconstriction in murine splenic vessels; leaves open translation to human vascular regulation.

Structured PICO

Population

Small splenic arteries (~150-microm diameter) and veins (~250-microm diameter) dissected from male GC-A-deficient 129sv mice or age-matched wild-type controls

Intervention

Atrial Natriuretic Peptide (ANP)

Comparator

Wild-type controls; intact vs denuded vessels

Outcome

Vasoconstriction (change in tension from baseline)surrogate

ANP causes vasoconstriction in the murine splenic vasculature via an endothelium-independent mechanism mediated by guanylyl cyclase.

Cite This Study

Andrew et al. (2003) studied this question.

synapsesocial.com/papers/6a7ec67b2540bc8e230269b2 https://doi.org/10.1152/ajpregu.00417.2002

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