Characterization and prognostic implications of infections associated with T-cell engagers in multiple myeloma

Lindsay Fogel; Harsh Parmar; Shucen Wan; Pooja Phull; Kimberly Doucette; Adolfo Aleman; Palka Anand; Joseph Franz; David Vesole; David Siegel; Noa Biran

doi:10.1080/10428194.2026.2714341

August 11, 2026Leukemia & lymphoma/Leukemia and lymphoma

Characterization and prognostic implications of infections associated with T-cell engagers in multiple myeloma

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Key Points

To evaluate the incidence, clinical spectrum, and prognostic impact of infections in patients receiving T-cell engager therapies for relapsed/refractory multiple myeloma.
Assessed infection profiles and clinical outcomes in patients undergoing treatment with T-cell engagers for heavily pretreated relapsed/refractory multiple myeloma.
Identified distinct clinical characteristics and rates of severe infections associated with T-cell engager therapy.
Demonstrated that therapy-associated infections significantly influence overall prognosis and treatment continuity.

Implication

Observational analysis characterizes infection patterns in relapsed multiple myeloma, highlighting substantial prognostic risks from T-cell engagers.

Abstract

Despite recent therapeutic advances, relapsed/refractory multiple myeloma (RRMM) remains difficult to treat. T-cell engagers (TCEs) are a promising option for heavily pretreated RRMM. These agents ...

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Cite This Study

Fogel et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec707b70b84ec8b91319d https://doi.org/10.1080/10428194.2026.2714341

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Characterization and prognostic implications of infections associated with T-cell engagers in multiple myeloma

Key Points

Implication

Abstract

Discussion

Cite This Study

Characterization and prognostic implications of infections associated with T-cell engagers in multiple myeloma

Key Points

Implication

Abstract

Discussion

Cite This Study

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