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August 14, 2026Journal of Child and Adolescent Psychopharmacology

Affective Neuroscience Personality Scales as Indicators of SSRI Treatment Response in Youths with Major Depressive Episodes: A Retrospective Cohort Study

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Authors

DLDohyeong LeeMLMinseok LeeKDKenneth L. Davis

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Overview

Retrospective cohort study reveals that specific emotional personality traits predict poorer SSRI response in depressed youth, indicating potential targets for personalized psychiatric care.

Key Points

  • To determine whether Affective Neuroscience Personality Scales (ANPS) baseline emotional traits are associated with SSRI treatment response in youth experiencing major depressive episodes.
  • Retrospective cohort analysis of medical records from 142 youths (aged 12–20 years) treated with SSRIs at a single university hospital.
  • Tracked primary outcomes with the Clinical Global Impression (CGI) scale and secondary outcomes with the Children’s Depression Inventory (CDI) and SCARED at baseline, 3, and 6 months, adjusting for demographic, developmental, clinical, and trauma covariates.
  • Higher baseline ANPS SADNESS (OR = 0.92, p = 0.033) and CARE (OR = 0.93, p = 0.043) scores significantly reduced the odds of achieving treatment response (CGI-I ≤2) at 6 months.
  • Linear mixed models demonstrated that higher SADNESS (β = 0.007, p = 0.031) and CARE (β = 0.009, p = 0.005) scores were significantly associated with a slower rate of improvement on the CGI-Severity scale over time.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec707b70b84ec8b91322ahttps://doi.org/10.1177/10445463261477334
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