Experimental study demonstrates red-emitting, circularly polarized luminescent spiro-carbofluoresceins with cellular permeability, indicating their utility for advanced optical bioimaging.
Chiral fluorescent probes based on small organic molecules present a promising platform for advanced bioimaging applications. In this work, we have developed a helically chiral spiro-shaped carbofluorescein with red emission (λem ≤ 613 nm). Configurationally stable enantiomers were separated, and electronic circular dichroism (ECD) and circularly polarized luminescence (CPL) evaluated. Preliminary results showed cellular permeability and intracellular emission.
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Erviti-Marticorena et al. (2026) studied this question.
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