Postintensive Care Frailty of Older Patients With Septic Shock: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial

Ryo Yamamoto; Takahiro Yamanaka; Daiki Kaito; Akia Endo; Kazuma Yamakawa; Takashi Tagami; Yutaka Umemura; 淳一 佐々木

doi:10.1097/ccm.0000000000007304

August 12, 2026Critical Care Medicine

Postintensive Care Frailty of Older Patients With Septic Shock: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial

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Key Points

To identify clinical characteristics and therapeutic factors associated with postintensive care frailty deterioration in older adults recovering from septic shock.
Conducted a post hoc analysis of a multicenter randomized controlled trial evaluating blood pressure targets in 513 older patients (≥65 years) with septic shock across ICUs in Japan.
Categorized 90-day frailty in 339 survivors using the Clinical Frailty Scale (CFS: ≤4 no-to-mild, 5–6 moderate, ≥7 severe) and analyzed risk factors using ordinal logistic regression with generalized estimating equations.
At 90 days post-ICU, 30.4% (103/339) of survivors had no-to-mild frailty, 33.6% (114/339) had moderate frailty, and 36.0% (122/339) had severe frailty.
Independent predictors of greater frailty included higher pre-sepsis CFS (aOR, 2.03; 95% CI, 1.72–2.40; p < 0.001), higher SOFA score (aOR, 1.16; 95% CI, 1.06–1.26; p < 0.001), and corticosteroid treatment (aOR, 1.72; 95% CI, 1.14–2.61; p < 0.001).
Corticosteroid use was notably associated with frailty progression in patients with baseline frailty (CFS ≥ 5), whereas SOFA score was associated with frailty in patients with tissue hypoperfusion (lactate ≥ 2 mmol/L).

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Implication

Randomized trial secondary analysis reveals baseline frailty, organ dysfunction, and corticosteroids predict 90-day post-ICU frailty in septic shock, highlighting key targets for recovery.

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Cite This Study

Yamamoto et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec71db70b84ec8b9133fd https://doi.org/10.1097/ccm.0000000000007304

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Postintensive Care Frailty of Older Patients With Septic Shock: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Postintensive Care Frailty of Older Patients With Septic Shock: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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