Meta-Environment No10: Molecular Signaling – An Integrative Chemical Communication Network That Determines Systemic Homeostasis and Aging

Molecular signaling has long been considered in biology as a set of disparate intracellular cascades: each receptor, each pathway was studied in isolation, outside the systemic context. Modern data require a fundamental revision of this idea. Molecular signaling is an integrated, dynamic, body-wide network of hormones, cytokines, growth factors, neurotransmitters, chemokines, lipid mediators, and their receptors that enables a continuous dialogue between cells, tissues, organs, and meta-environments. This system is the chemical language of the body, in which all regulatory functions are recorded, from maintaining basal homeostasis to adapting to stress, inflammation, and aging. We substantiate that signaling is not just a set of paths, but an active meta-environment No10. Particular attention is paid to the phenomenon of metainflammation — a chronic increase in pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), which is a key driver of aging, atherosclerosis, insulin resistance, and neurodegeneration. Systemic restoration of signal homeostasis in the Quatotron method is presented, aimed at restoring sensitivity to signaling molecules and rejuvenating systemic regulation.