What question did this study set out to answer?

To systematically evaluate the association between assisted reproductive technology (ART) and autism spectrum disorder (ASD) using large population-based cohort studies.

August 14, 2026Bratislavské lekárske listy/Bratislava medical journalOpen Access

Association Between Assisted Reproductive Technology and Autism Spectrum Disorder

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To systematically evaluate the association between assisted reproductive technology (ART) and autism spectrum disorder (ASD) using large population-based cohort studies.
Conducted a systematic review and random-effects meta-analysis of peer-reviewed cohort studies with >500,000 births.
Included 5 large cohort studies comprising over 12 million births that adjusted for maternal age, paternal age, parity, and sociodemographic confounders.
Pooled analysis demonstrated a statistically significant association between ART exposure and ASD (hazard risk ratio 1.26, 95% CI 1.08–1.49).
Substantial between-study heterogeneity was observed (I² = 74%), indicating that underlying parental subfertility or specific clinical procedures may largely account for the modest observed risk.

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Implication

Meta-analysis shows modest increased risk of autism spectrum disorder following assisted reproductive technology, suggesting underlying parental subfertility may drive the association.

Cite This Study

Peña et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec7aab70b84ec8b91440f https://doi.org/10.1007/s44411-026-00769-x

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Implication

Meta-analysis shows modest increased risk of autism spectrum disorder following assisted reproductive technology, suggesting underlying parental subfertility may drive the association.

Association Between Assisted Reproductive Technology and Autism Spectrum Disorder

Key Points

Discussion

Implication

Cite This Study

Association Between Assisted Reproductive Technology and Autism Spectrum Disorder

Key Points

Discussion

Implication

Cite This Study

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