A combined attack: Hydrogen-bonding interactions with double Lewis acid activation generate a dinuclear ZnII complex that is exceptionally effective for binding monoanionic phosphate diesters in water and for catalyzing phosphodiester transesterifications. The complex catalyzes the hydrolytic cleavage of RNA-like activated, artificial substrates and nonactivated, natural substrates with similar efficiencies.
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Feng et al. (2006) studied this question.
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