Key result
Children aged 1 year or younger had a significantly higher risk of hand, foot and mouth disease reinfection compared to 5-year-old children (OR 20.65).
Why the study?
Hand, foot and mouth disease (HFMD) reinfection is common due to limited cross-protection between enterovirus strains, but its epidemiological characteristics and influential factors needed investigation.
Population
369,054 HFMD patients aged ≤5 yr in Guangzhou, China
Comparison
Patients with HFMD reinfection vs single infection
Design
Surveillance system-based observational study
Authors
Loading...
May warrant intensified hygiene counseling for infants after first HFMD; leaves open whether targeted interventions can reduce this observational risk.
Observational (n=369,054)
Odds Ratio: 20.65 (95% CI 14.46–29.48)
Absolute Event Rate: 3.86% vs 0.19%
p-value: p=<0.001
HFMD reinfection occurs in approximately 3% of cases among children under 5, with highest risks in infants, males, and rural residents, highlighting the need for targeted prevention strategies.
Zhong et al. (2022) conducted an observational in Hand, Foot and Mouth Disease (HFMD) (n=369,054). Age ≤1 year vs. Age 5 years was evaluated on HFMD reinfection (OR 20.65, 95% CI 14.46-29.48, p=<0.001). Children aged 1 year or younger had a significantly higher risk of hand, foot and mouth disease reinfection compared to 5-year-old children (OR 20.65).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: