October 13, 2008Cardiovascular ResearchOpen Access

MMP-9 and -12 cause N-cadherin shedding and thereby β-catenin signalling and vascular smooth muscle cell proliferation

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Population

Mouse aortic vascular smooth muscle cells deficient in MMP-9 and MMP-12 and wild-type controls

Comparison

MMP-9 or -12 deficiency, siRNA knockdown, or… vs Wild-type controls or control siRNA

Design

Preclinical

Authors

SSSadie C. SlaterBristol Royal Infirmary SGSarah J. GeorgeHealth & Life (Taiwan)

Discussion

Member takes

Implication

Hypothesis-generating for MMP-9/12 inhibition to curb VSMC proliferation; no practice change from animal data alone.

Structured PICO

Population

Mouse aortic vascular smooth muscle cells (VSMCs) deficient in MMP-9 (MMP-9-/-) and MMP-12 (MMP-12-/-) and wild-type controls

Intervention

MMP-9 or -12 deficiency (knockout), siRNA knockdown, or incubation with active MMP-9 or -12

Comparator

Wild-type controls or control siRNA

Outcome

N-cadherin shedding, beta-catenin signalling, and VSMC proliferationsurrogate

MMP-9 and MMP-12 promote vascular smooth muscle cell proliferation by cleaving N-cadherin and elevating beta-catenin signalling, suggesting a mechanism for intimal thickening in restenosis and atherosclerosis.

Cite This Study

Slater et al. (2008) studied this question.

synapsesocial.com/papers/6a7ef1be57c13562f39b2897 https://doi.org/10.1093/cvr/cvn278

View Full Paper

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Bookmark

MMP-9 and -12 cause N-cadherin shedding and thereby β-catenin signalling and vascular smooth muscle cell proliferation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

MMP-9 and -12 cause N-cadherin shedding and thereby β-catenin signalling and vascular smooth muscle cell proliferation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider