The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a ‘one pot’ procedure. The intermediate Claisen–Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.
No takes yet. Share an insight, caveat, or question.
Smith et al. (2007) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: