Amyloidosis: Its Clinical and Pathologic Manifestations, With a Report of 12 Cases

Article1 May 1957AMYLOIDOSIS: ITS CLINICAL AND PATHOLOGIC MANIFESTATIONS, WITH A REPORT OF 12 CASESGEORGE L. BERO, M.D.GEORGE L. BERO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-5-931 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmyloidosis is a generalized disease characterized by the deposition of a homogeneous substance in the media of arteries and perivascular connective tissues. Because of its starchlike staining with iodine, Virchow (1853) considered the substance a carbohydrate moiety, and originated the term "amyloid." The chemical nature of amyloid has never been clearly elucidated, but the studies of Eppinger (1922) and Hass (1940)21demonstrated the presence of both protein and polysaccharide elements. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: West Roxbury, Massachusetts*Received for publication August 13, 1956.From the Veterans Administration Hospital, West Roxbury, Massachusetts.Requests for reprints should be addressed to George L. Bero, M.D., Veterans Administration Hospital, West Roxbury 32, Massachusetts. 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