Key result
Lower estimated glomerular filtration rate was an independent predictor of short-term death and heart failure hospitalization in elderly patients with HFpEF (OR 0.95, 95% CI 0.93-0.98).
Why the study?
To investigate whether decreased renal function assessed by eGFR is an independent predictor of death and new hospitalizations in elderly patients hospitalized with heart failure with preserved ejection fraction.
Does estimated glomerular filtration rate (eGFR) predict short-term death and heart failure hospitalization in elderly patients with acute heart failure with preserved ejection fraction?
Cohort (n=102)
No
Does estimated glomerular filtration rate (eGFR) predict short-term death and heart failure hospitalization in elderly patients with acute heart failure with preserved ejection fraction?
In elderly patients hospitalized with acute HFpEF, reduced eGFR is an independent predictor of short-term mortality and heart failure readmission.
Hypothesis-generating for eGFR in elderly HFpEF risk models; leaves open prospective validation before any practice change.
Heart failure with preserved ejection fraction is a frequent condition among the elderly. The prevalence of chronic kidney disease is also very high, accounting for 5-10% of the population. The aim of this study was to investigate whether the decrease in renal function, assessed by estimated glomerular filtration rate (eGFR), was an independent predictor of adverse events such as death and new hospitalizations in elderly patients hospitalized with heart failure with preserved ejection fraction. This study included hospitalized patients diagnosed with heart failure with preserved ejection fraction. Renal function was estimated by calculating glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration formula. Patients were stratified into two cohorts using the median eGFR value of 45.45 mL/min/1.73 m2 as the cutoff. During a 3-month follow-up, a total of 30 events were recorded. Multivariate logistic analysis adjusted for confounding factors such as age, gender, anemia, and therapy revealed that eGFR was an independent predictive factor in various models: odds ratio (OR): 0.96, 95% confidence interval (CI) 0.93-0.99, p=0.016; OR: 0.95, 95% CI 0.93-0.98, p=0.003. GFR is an independent predictive factor of short-term events in a population of elderly patients with heart failure with preserved ejection fraction.
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Carpini et al. (2025) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF) (n=102). Estimated glomerular filtration rate (eGFR) vs. Higher eGFR was evaluated on Adverse events (death and new hospitalizations due to HF) (OR 0.95, 95% CI 0.93-0.98, p=0.003). Lower estimated glomerular filtration rate was an independent predictor of short-term death and heart failure hospitalization in elderly patients with HFpEF (OR 0.95, 95% CI 0.93-0.98).
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