NPC1L1 on pancreatic adenocarcinoma cell functions as a two-pronged checkpoint against antitumor activity

Ruiyang Zi; Kaicheng Shen; Pengfei Zheng; Xingxing Su; Yishi Yang; Yanrong Chen; Chengyi Mao; Yongling Lu; Liting Wang; Hongbo Ma; Wei Wang; Qing Yun Li; Wei-Ting Lu; Chengtao Li; Shuangjia Zheng; Hui Shi; Xiaohong Liu; Zhiyu Chen; Houjie Liang; Juanjuan Ou

doi:10.1016/j.xinn.2024.100783

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Abstract

T cells, and improved the anti-tumor immunity of PAAD to synergize with PD-1 blockade, suggesting NPC1L1 as a promising target to rescue the anti-tumor activity in PAAD.

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Zi et al. (2025) studied this question.

synapsesocial.com/papers/6a7f14e2c95b32c6ab8ec1b3 https://doi.org/10.1016/j.xinn.2024.100783

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NPC1L1 on pancreatic adenocarcinoma cell functions as a two-pronged checkpoint against antitumor activity

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NPC1L1 on pancreatic adenocarcinoma cell functions as a two-pronged checkpoint against antitumor activity

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