Key result
A genome-wide association meta-analysis identified four risk loci for fibromuscular dysplasia, with the strongest association at the PHACTR1 locus (OR 1.44), and demonstrated shared genetics with common cardiovascular diseases.
Meta-Analysis (n=8,656)
Yes
Odds Ratio: 1.44 (95% CI 1.31–1.57)
p-value: p=5x10^-15
No takes yet. Share an insight, caveat, or question.
Should not yet change FMD diagnosis or management; leaves open functional and translational studies of shared vascular genetics.
Georges et al. (2021) conducted a meta-analysis in Fibromuscular dysplasia (n=8,656). Genetic risk variants (e.g., rs9349379 in PHACTR1) vs. Reference allele / Controls was evaluated on Association with fibromuscular dysplasia risk (lead SNP rs9349379) (OR 1.44, 95% CI 1.31-1.57, p=5x10^-15). A genome-wide association meta-analysis identified four risk loci for fibromuscular dysplasia, with the strongest association at the PHACTR1 locus (OR 1.44), and demonstrated shared genetics with common cardiovascular diseases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: