What question did this study set out to answer?

To evaluate the impact of social and environmental factors, such as smoking, alcohol consumption, and occupational adjustment, on the risk of angina pectoris while controlling for genetic background.

January 1, 1976American Journal of Epidemiology

Background of Angina Pectoris: Social and Environmental Factors in Relation to Smoking

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Why the study?

Are social and environmental factors such as alcohol drinking and smoking independently associated with angina pectoris?

Population

About 5200 male twin pairs from the Registry at the Karolinska Institute, Stockholm, and the Registry of the…

Comparison

Social and environmental factors including… vs Absence of these factors

Design

Cross-sectional

Authors

ZHZdenek HrubecNational Institutes of Health RCRune CederlöfSwedish National Heritage Board LFLars FribergNational Board of Health and Welfare

Discussion

Member takes

Implication

Alcohol intake may warrant attention beyond genetics in angina; leaves open causality pending prospective twin studies.

Key Points

To evaluate the impact of social and environmental factors, such as smoking, alcohol consumption, and occupational adjustment, on the risk of angina pectoris while controlling for genetic background.
Analyzed questionnaire data from approximately 1,200 male twin pairs from the Karolinska Institute Registry (Sweden) and approximately 4,000 male twin pairs from the National Research Council Registry (US).
Evaluated individual-level associations and conducted co-twin control analyses in monozygous and dizygous twin pairs discordant for lifestyle and environmental factors.
Individual-level analysis showed significant associations between angina pectoris and alcohol consumption, lack of exercise, frequent employer changes, low occupational adjustment, and smoking.
In discordant monozygous twin pairs, significantly different rates of angina pectoris appeared only in relation to alcohol consumption.
In discordant dizygous twin pairs, significantly different rates of angina pectoris were observed with alcohol consumption and low occupational adjustment.

Structured PICO

Are social and environmental factors such as alcohol drinking and smoking independently associated with angina pectoris?

Population

About 5200 male twin pairs (~10,400 individuals) from the Registry at the Karolinska Institute, Stockholm, and the Registry of the National Research Council, Washington, DC.

Intervention

Social and environmental factors including alcohol drinking, lack of exercise, frequent change of employer, low occupational adjustment, and smoking

Comparator

Absence of these factors (analyzed via discordant twin pairs)

Outcome

Angina pectoris (based on an operational definition developed from questionnaire data)patient reported

Alcohol drinking and occupational adjustment are directly related to angina pectoris, independent of genetic background and other factors.

Cite This Study

Hrubec et al. (1976) studied this question.

synapsesocial.com/papers/6a7f2aedb1a7ff7f700dfc54 https://doi.org/10.1093/oxfordjournals.aje.a112201

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Background of Angina Pectoris: Social and Environmental Factors in Relation to Smoking

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Background of Angina Pectoris: Social and Environmental Factors in Relation to Smoking

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider