Key result
A 28-year-old man developed secondary hypogonadism with bilateral gynecomastia and erectile dysfunction two weeks after hand, foot, and mouth disease, which spontaneously resolved after one month.
Why the study?
Hypogonadism has been linked to viral infections, but secondary hypogonadism following hand, foot, and mouth disease had not been reported.
Case Report (n=1)
No
This is the first reported case of secondary hypogonadism following hand, foot, and mouth disease in an adult, which resolved spontaneously within one month.
Answers are grounded in this paper and cite their sources.
May link HFMD to transient adult hypogonadism; leaves open causality and needs confirmatory reports.
BACKGROUND: Previous reports have described hypogonadism associated with virus infection such as hantavirus, human immunodeficiency virus (HIV) or severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). However, to our best knowledge there has been no case report of secondary hypogonadism following hand, foot, and mouth disease (HFMD). CASE PRESENTATION: A previously healthy 28-year-old man with no history of major physical and psychological trauma, presented with bilateral gynecomastia and erectile dysfunction 2 weeks after HFMD. Laboratory testament showed the level of gonadotropin hormones declined. Imaging examination demonstrated no major abnormal change in pituitary or reproductive system. The diagnosis of hypogonadism was established. Then the patient was ordered to maintain mental health outward of hospital without drug intervention. One month after presentation, his gonadotropin hormone level and sexual desire had recovered, while bilateral gynecomastia and erectile dysfunction symptoms disappeared. CONCLUSIONS: Physicians should notice the possibility for hypogonadism in adult patients with a recent history of HFMD.
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Chen et al. (2022) conducted a case report in Secondary hypogonadism following hand, foot, and mouth disease (n=1). Hand, foot, and mouth disease (HFMD) was evaluated on Development and recovery of secondary hypogonadism. A 28-year-old man developed secondary hypogonadism with bilateral gynecomastia and erectile dysfunction two weeks after hand, foot, and mouth disease, which spontaneously resolved after one month.
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