June 1, 2018EuroIntervention4 citations
View Full PaperAssociation between coronary atherosclerosis progression and in-stent neoatherosclerosis in patients with ST-elevation myocardial infarction at five-year follow-up
Key Result
In-stent neoatherosclerosis (21.0%) and signal-rich bands (35.5%) at 5 years were associated with stent-related factors but not with atherosclerosis progression in non-culprit segments.
Study Design
Type
Observational (n=62)
PICO
P
Population
62 patients with ST-elevation myocardial infarction from the EXAMINATION study who underwent optical coherence tomography at 5-year follow-up.
E
Exposure / Comparator
In-stent neoatherosclerosis and signal-rich bands
O
Primary Outcome
Association between in-stent neoatherosclerosis and atherosclerosis progression in non-culprit segments
Abstract
AIMS: The aim of the study was to investigate the association between in-stent neoatherosclerosis (NA) and atherosclerosis progression (AP) in non-culprit segments in patients with ST-elevation myocardial infarction at five years. METHODS AND RESULTS: Sixty-two out of 169 consecutive patients included in the EXAMINATION study underwent optical coherence tomography (OCT) at five years. NA plaques were observed in 13 (21.0%), signal-rich bands (SRB) in 22 (35.5%) and AP in 11 (17.7%). NA plaques were more frequently observed in patients treated with two stents (53.8% vs. 20.4%; p=0.02). SRB were more frequently observed with longer stent length (29.8±11.6 vs. 22.5±9.1 mm; p<0.01), larger stent size (3.4±0.4 vs. 3.1±0.4 mm; p<0.01) and with bare metal stents (BMS) (68.2% vs. 40.0%; p=0.03). Patients with AP had higher levels of LDL-cholesterol (108.3±27.1 vs. 86.3±27.6 mg/dl; p=0.02). QCA of 744 non-culprit segments showed no association between NA plaques or SRB and reduction of lumen diameters. By multivariate analysis, NA plaques were associated with stent length; SRB were associated with stent length and BMS. AP was associated with mean LDL-cholesterol levels. CONCLUSIONS: NA and SRB had no association with AP or with LDL-cholesterol. NA and SRB were associated with stent-related factors such as stent length and BMS. AP was associated with LDL-cholesterol levels.
Cite This Study
Paoletti et al. (Fri,) conducted a observational in ST-elevation myocardial infarction (n=62). In-stent neoatherosclerosis and signal-rich bands was evaluated on Association between in-stent neoatherosclerosis and atherosclerosis progression in non-culprit segments. In-stent neoatherosclerosis (21.0%) and signal-rich bands (35.5%) at 5 years were associated with stent-related factors but not with atherosclerosis progression in non-culprit segments.