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NADH supplementation had no effect on VO2max or anaerobic performance; challenges ergogenic claims and leaves open need for larger trials.
The aim of this study was to assess the effects of nicotinamide adenine dinucleotide hydride (NADH) on maximal oxygen uptake (VO2max), maximal anaerobic running time, and mental performance. Eight men were exposed to a supplement treatment (30 mg NADH as ENACHI tablets per day) and to a placebo treatment, each of 4 weeks' duration, in a balanced, double-blind, and cross-over design. The two treatments were separated by a 14-week wash-out period. The results indicated that VO2max, maximal anaerobic running time, and the ability to concentrate were similar in the NADH and placebo conditions. There were also no differences in blood lactate, creatine kinase, reaction time or feelings of fatigue between the treatments. A counter-movement jump performed at rest and 2 min after the aerobic test differed significantly (P <or= 0.05) between the treatment conditions and was higher in the NADH group. In conclusion, the NADH supplementation for 4 weeks had no effects on VO2max, maximal anaerobic running time or mental performance.
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Mero et al. (2007) studied this question.
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