The E311A/R312A mutation in yeast actin alters motility in the presence of tropomyosin and troponin without affecting tropomyosin binding, implicating allosteric effects in actomyosin regulation.
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Does not inform clinical practice; extends mechanistic insight into thin-filament allosteric control of actomyosin.
Gerson et al. (1999) studied this question.
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