Key result
Elevated waist-hip ratio (≥0.98 for males, ≥0.97 for females) was associated with a lower likelihood of achieving therapeutic targets for LDL-C (p=0.05), HDL-C (p<0.001), and TG (p<0.001).
Why the study?
The study aimed to determine associations between different anthropometric indices (BMI, WC, and WHR) and attainment of therapeutic lipid goals in patients with atherosclerotic CVD undergoing secondary prevention.
Does elevated waist-hip ratio correlate with a lower likelihood of achieving therapeutic lipid goals in patients with atherosclerotic CVD undergoing secondary prevention?
Cross-Sectional (n=5,718)
Yes
Does elevated waist-hip ratio correlate with a lower likelihood of achieving therapeutic lipid goals in patients with atherosclerotic CVD undergoing secondary prevention?
Elevated waist-hip ratio is a simple anthropometric marker associated with a lower likelihood of achieving therapeutic lipid goals in patients undergoing secondary prevention for CVD.
Should not yet change lipid management; leaves open whether waist-hip ratio identifies residual risk requiring intensified secondary prevention.
BACKGROUND: Body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR) are all simple anthropometric tools used to categorize obesity status. This study aimed to determine associations between different anthropometric indices and the attainment of therapeutic lipid goals in patients with atherosclerotic cardiovascular disease (CVD) undergoing secondary prevention. METHODS: Between 2010 and 2014, this multi-center study enrolled 5718 patients undergoing secondary prevention for CVD. At study enrollment, total cholesterol, high-density lipoprotein protein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) were recorded. This cross-sectional study analyzed these three anthropometric obesity indices and correlations with achieving therapeutic lipid goals. RESULTS: Among the 5718 patients, multivariate analysis revealed that those with higher BMI or WC tended not to meet their HDL-C and TG therapeutic goals. However, neither BMI nor WC showed a relationship with achieving the LDL-C target. The patients with an elevated WHR (≥ 0.98 for males and ≥ 0.97 for females) were less likely to achieve all three lipid target values, including LDL-C (p = 0.05), HDL-C (p < 0.001) and TG (p < 0.001). CONCLUSIONS: Among Taiwanese patients undergoing secondary prevention for CVD, the higher the WHR the lower the likelihood of achieving the lipid therapeutic goals.
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Tsai et al. (2019) conducted a cross-sectional in Atherosclerotic cardiovascular disease (CVD) (n=5,718). Elevated waist-hip ratio (WHR) vs. Lower waist-hip ratio was evaluated on Achieving therapeutic lipid goals (LDL-C, HDL-C, and TG) (p=0.05 for LDL-C, <0.001 for HDL-C and TG). Elevated waist-hip ratio (≥0.98 for males, ≥0.97 for females) was associated with a lower likelihood of achieving therapeutic targets for LDL-C (p=0.05), HDL-C (p<0.001), and TG (p<0.001).
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