Key result
Vascular smooth muscle cells isolated from abdominal aortic aneurysms displayed increased mitochondrial fragmentation, higher ROS production, and more DNA damage compared to healthy controls.
Why the study?
The role of mitochondria and oxidative stress in vascular remodelling and progression of abdominal aortic aneurysms remains uncertain.
Population
10 AAA-derived VSMC cultures and 7 normal VSMC cultures from healthy donors
Comparison
AAA-SMC vs healthy control VSMC cultures in the presence or absence of AngII
Design
In vitro comparative study
Authors
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Should not yet change AAA practice; leaves open VSMC mitochondria as a therapeutic target.
Mitochondrial dysfunction and oxidative stress are persistently increased in vascular smooth muscle cells from abdominal aortic aneurysms, highlighting their role in AAA pathophysiology.
Tavris et al. (2023) studied Abdominal aortic aneurysm (n=17). Abdominal aortic aneurysm (AAA) condition vs. Normal VSMCs from healthy donors was evaluated on Mitochondrial dysfunction, ROS production, NADP+/NADPH content, and DNA damage. Vascular smooth muscle cells isolated from abdominal aortic aneurysms displayed increased mitochondrial fragmentation, higher ROS production, and more DNA damage compared to healthy controls.
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