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Water-soluble fluorescent core/shell nanoparticles containing multiple -COOH groups are synthesized via atom-transfer radical polymerization by applying perylenediimide derivatives as the template. This novel dye combines good water-solubility and attractive optical properties. It specifically stains the cell nucleus by binding to positively charged nuclear proteins (see image).
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Yin et al. (2008) studied this question.
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