Progressive Lenticular Degeneration: A Familial Nervous Disease Associated With Cirrhosis of the Liver1

amenorrhœa.Menstruation is now rather too frequent.There has been a gain in weight of 141b. in four months.No tubercle bacilli have been found in the last six examinations.CHART 5.-Woman, aged 20.Two years' history of illness; infiltra- tion throughout right lung, and in apex of left lung.The temperature in this case was the same as, or higher than, in the first 12 days of the chart.The chart shows the effect of the oral administration of Burroughs, Wellcome, and Co.'s tuberculin W. The temperature continued to be satisfactory.CHART 6.-Man, aged 26.First seen after a month's history.Acute caseous tuberculosis in upper lobes on both sides.Tubercle bacilli present.Absolute rest for a week produced little effect.The admini- stration of tuberculin by the mouth was followed rapidly by a cessation of fever, and it is possible here to see the effect of each dose given.In a month's time the temperature became normal.The patient was subsequently sent to a sanatorium, and is now at work.CHART 7.-Man, aged 32Taken suddenly ill with high fever and 'rigors.Four days subsequently he was admitted to St. George's Hospital.He was emaciated, semi-comatose, and had occasional rigors.Absolute rest was tried for a week without effect.As the clmical symptoms suggested a diagnosis of acute tuberculosis, the opsonic index for this infection was taken on the seventh day.When the temperature was normal the index was 1-75 and when the temperature was 104° F. the index was 0'73.1/20000 mg. of tuberculin was .administeredby the mouth in the early morning of the eighth day.The temperature fell and did not rise again for 36 hours.A further dose of tuberculin of the same size was given and a similar effect produced.It was argued that tuberculin had a definite effect, but that as the effect of the dose wore off quickly it would be advisable to give the .doseat shorter intervals-viz., 24 instead of 48 hours.This was done and the temperature fell to normal.The doses of tuberculin were gradually increased and given at longer intervals.The patient recovered and gained 2 st. in the hospital.He was reported to be well and at work two years after treatment.CHART 8.-Man, aged 19.Six months' history of tuberculous pleurisy.This chart shows the result of oral administration in a susceptible case.'Tuberculin was continued in this case with good results.CHART 9.-Woman, aged 22. Eighteen months' history.Infiltration throughout right lung, and to a slight extent in apex of left lung.Tubercle bacilli present.Under observation without improvement at Northwood Sanatorium for six months.The chart shows the apparent effect of the oral administration of a minute dose of B.E. Subsequently an artificial pneumothorax was induced, and the patient at the present time is having nitrogen injections and tuberculin, CHART 10.-Man, aged 33.Two and a half years' history.Infiltra- tion apex of right upper and 10Vler lobes and in the left upper apex.Tubercle bacilli present.This chart shows (a) a dose of 1/30 mg.T.R.