A Novel Method in the Stratification of Post-Myocardial-Infarction Patients Based on Pathophysiology

Ben He; Heng Ge; Fan Yang; Yujun Sun; Li Zheng; Meng Jiang; Yiting Fan; Jun Pu; Xuedong Shen

doi:10.1371/journal.pone.0130158

June 19, 2015PLoS ONEOpen Access

A Novel Method in the Stratification of Post-Myocardial-Infarction Patients Based on Pathophysiology

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Why the study?

Does a novel pathophysiological classification predict 90-day MACEs in first-time STEMI patients?

Structured PICO

Does a novel pathophysiological classification predict 90-day MACEs in first-time STEMI patients?

P

Population

180 first-time STEMI patients who received reperfusion therapy within 12h of symptom onset, with available CMR data within hospitalization.

I

Intervention

Stratification into 5 grades based on pathophysiological changes (Grade 0: no detectable myocardial necrosis; Grade 1: myocardial necrosis without functional/morphological abnormalities; Grade 2: myocardial necrosis with reduced LVEF; Grade 3: reduced LVEF with cardiac remodeling; Grade 4: mitral regurgitation additional to Grade-3 criteria).

O

Outcome

90-day MACEs (composite of any death, resuscitated cardiac arrest, acute heart failure, and stroke)composite

A novel pathophysiological classification using CMR and echocardiography effectively stratifies post-STEMI patients and independently predicts 90-day major adverse cardiovascular events.

Limitations

Small sample size due to the high cost of CMR
Criteria may be further refined to achieve a more precise stratification

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Implication

May support post-STEMI risk stratification; hypothesis-generating and requires prospective validation before clinical adoption.

Abstract

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Cite This Study

He et al. (2015) studied this question.

synapsesocial.com/papers/6a7f4ad881e360e959d6877b https://doi.org/10.1371/journal.pone.0130158

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A Novel Method in the Stratification of Post-Myocardial-Infarction Patients Based on Pathophysiology

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A Novel Method in the Stratification of Post-Myocardial-Infarction Patients Based on Pathophysiology

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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