Population
Hep G2 cells (in vitro model)
Comparison
Niacin at concentrations of 0 to 3.0 mmol/L vs Baseline (no niacin)
Design
Preclinical
Authors
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Niacin may augment reverse cholesterol transport via reduced hepatic apoA-I uptake; hypothesis-generating in Hep G2 cells, needs in vivo confirmation.
Niacin selectively decreases hepatic removal of HDL apoA-I but not cholesterol esters in Hep G2 cells, suggesting a mechanism for its ability to augment reverse cholesterol transport.
Kamanna et al. (1997) studied this question.
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