Since Sudoku was invented, it has been an open problem to find the minimum-clue Sudoku puzzles, also commonly called the minimum Sudoku problem. Solving the problem can be done by checking 5,472,730,538 essentially different Sudoku grids independentl
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Lin et al. (2011) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: