Answers are grounded in this paper and cite their sources.
Small-molecule heterobifunctional degraders can effectively control protein levels and are useful research tools. We assembled proteolysis targeting chimeras (PROTACs) from a cereblon (CRBN) and a von-Hippel-Lindau (VHL) ligase ligand and demonstrated a PROTAC-induced heterodimerization of the two E3 ligases leading to unidirectional and efficient degradation of CRBN.
No takes yet. Share an insight, caveat, or question.
Steinebach et al. (2019) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: