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February 19, 2014Journal of Clinical OncologyOpen Access

Age-Related Decline in DNA Repair Function Explains Diminished Ovarian Reserve, Earlier Menopause, and Possible Oocyte Vulnerability to Chemotherapy in Women With BRCA Mutations

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Authors

KOKutluk OktayYale UniversityFMFred MoyNew York Medical CollegeSTShiny TitusColumbia University Irving Medical Center

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Oktay et al. (2014) studied this question.

synapsesocial.com/papers/6a7f5bbe0ef299495efbed6chttps://doi.org/10.1200/jco.2013.53.5369
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer.1996 · 821 citations
  2. 2Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans2013 · 525 citations
  3. 3Chemotherapy-Induced Amenorrhea in Patients With Breast Cancer With a BRCA1 or BRCA2 Mutation2013 · 73 citations
  4. 4Comparison of age at natural menopause in BRCA1/2 mutation carriers with a non–clinic‐based sample of women in northern California2013 · 145 citations