Mobility Matters—Rethinking Compression Therapy in Lymphedema and Phlebolymphedema

Lymphedema and phlebolymphedema are increasingly recognized as prevalent chronic conditions that extend beyond traditional cancer-related populations. Although Complete Decongestive Therapy remains the foundation of management, real-world treatment success is often limited by challenges with long-term adherence, particularly when therapies disrupt patients’ daily activities. This commentary explores the physiologic relationship between mobility and fluid transport, emphasizing the complementary roles of movement and compression in supporting venous and lymphatic return. Emerging evidence from studies of wearable, non-pneumatic compression technologies suggest that allowing patients to remain active during treatment may improve limb-volume reduction, quality of life, and adherence compared with conventional pneumatic systems. These findings challenge longstanding assumptions regarding immobilization and trunk compression while reinforcing the importance of patient-centered treatment strategies. As the burden of chronic edema continues to grow, clinicians should increasingly consider mobility as an active therapeutic component and prioritize interventions that align with both human physiology and the realities of everyday life.