Why the study?
Does L3HYPDH expression inhibit EV71 replication in human cell lines?
Does L3HYPDH expression inhibit EV71 replication in human cell lines?
L3HYPDH is a newly identified interferon-stimulated gene that inhibits EV71 replication by impairing viral IRES-mediated translation, revealing a novel host antiviral mechanism.
L3HYPDH may serve as a novel EV71 antiviral target; preclinical data leave open human therapeutic translation.
Enterovirus 71 (EV71) is the common causative agent of hand-foot-mouth disease (HFMD). Despite evidence in mice model suggested that the interferon (IFN) signaling pathways play a role in defending against this virus, knowledge on the IFN-mediated antiviral response is still limited. Here we identified an IFN-stimulated gene (ISG) called L3HYPHD, whose expression inhibits EV71 replication. Mapping assay indicated that amino acids 61-120 and 295-354 are critical for its optimal antiviral activity. Mechanismly, L3HYPDH specifically inhibits protein translation mediated by EV71 internal ribosome entry site (IRES). Our data thus uncovered a new mechanism utilized by the host cell to restrict EV71 replication.
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Liu et al. (2018) studied this question.
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