Why the study?
Does Holter ECG analysis of notched T waves improve the detection and differentiation of LQT2 mutations from LQT1 and controls?
Population
290 subjects, including carriers of mutations in KCNQ1 or HERG, and control subjects.
Comparison
Holter ECG recording analysis of T-wave… vs Control subjects and LQT1 mutation carriers.
Design
Cross-sectional
Authors
Loading...
May support Holter T-wave analysis for LQT2 suspicion; leaves open prospective validation before clinical adoption.
Does Holter ECG analysis of notched T waves improve the detection and differentiation of LQT2 mutations from LQT1 and controls?
Holter ECG analysis of T-wave morphology, specifically the presence of grade 2 notches, is highly specific for detecting LQT2 (HERG) mutations compared to LQT1 and healthy controls.
Lupoglazoff et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: