Cyanomethylation of chiral N-(tert-butylsulfinyl)imines with 2-trimethylsilylacetonitrile (TMSCH2CN) in the presence of a Lewis base such as tetrabutylammonium phenoxide (PhONn-Bu4) proceeds smoothly to afford the corresponding β-amino nitriles in good to high yields with excellent diastereoselectivities.
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Mukaiyama et al. (2007) studied this question.
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