Why the study?
Kidney damage is a serious complication of cardiopulmonary bypass, prompting investigation into new biomarkers such as NRF-2 for early detection.
Key points are not available for this paper at this time.
Design
Review article
Should not yet change practice for post-CPB AKI detection; leaves open whether NRF-2 is a valid early biomarker.
Cardiopulmonary bypass, which allows cardiac interventions, is a standard perfusion technique used in cardiac surgery, which provides cardiac arrest by using cardioplegic solutions and oxygenates the blood outside the body through extracorporeal circulation and redirects blood back to the patient. With the use of cardiopulmonary bypass technique, serious complications may develop in the perioperative and postoperative periods. One of the most important of these developing complications is kidney damage. New biomarkers that will enable the early detection of this developing kidney damage are being investigated, one of which is NRF-2. Our aim in this review article is to investigate current information about NRF-2 and to identify the role factors associated with kidney damage.
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Mahmut Padak (2023) studied this question.
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