Key result
DNase I improves rt-PA thrombolysis and reduces hemorrhagic transformation in acute ischemic stroke.
Targeting neutrophil extracellular traps with DNase I represents a promising strategy to overcome thrombolysis resistance and improve outcomes in acute ischemic stroke.
Acute ischemic stroke (AIS) is a life-threatening thrombotic disorder, with intravenous thrombolysis (IVT) serving as the first-line treatment during its acute phase. However, thrombolysis resistance diminishes the success rate of early reperfusion. Recent studies have highlighted neutrophil extracellular traps (NETs) as a critical factor contributing to thrombolysis resistance. Targeting NETs with deoxyribonuclease I (DNase I) has been shown to significantly improve the thrombolytic efficacy of recombinant tissue plasminogen activator (rt-PA) and reduce the risk of hemorrhagic transformation. In this review, we summarize current knowledge on the mechanisms by which NETs contribute to thrombosis and thrombolysis resistance, explore the prospective and feasibility of targeting NETs to improve thrombolysis, providing information about the creation of innovative thrombolytic treatment approaches for AIS.
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Wu et al. (2025) conducted a review in Acute ischemic stroke. Targeting neutrophil extracellular traps (NETs) with deoxyribonuclease I (DNase I) was evaluated. Targeting neutrophil extracellular traps with DNase I improves the thrombolytic efficacy of rt-PA and reduces the risk of hemorrhagic transformation in acute ischemic stroke.
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