The structural basis for polymorphism in amyloids is unraveled with a model system. The hydrogen-bonding pattern within the β sheets of fibrils is strongly influenced by the pH of the solution from which the fibrils are formed. Solid-state NMR spectroscopy experiments allow quantification of the relative amounts of two different β-sheet structures over the pH range 2.0–7.3.
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Verel et al. (2008) studied this question.
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